Evidence supporting the use of: Chirata
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Chirata (Swertia chirata) has a long history of use in traditional Ayurvedic and Unani medicine, where it is regarded as a "bitter tonic" with applications as an anthelmintic—used to expel intestinal worms and parasites, including nematodes. Classical Ayurvedic texts describe Chirata’s use for "krimi" (worms), and it is often included in herbal formulations aimed at treating parasitic infestations. The proposed mechanism, based on traditional knowledge, is that Chirata’s intense bitterness and phytochemical constituents (such as swertiamarin, amarogentin, and other secoiridoid glycosides) create an intestinal environment that is inhospitable to parasites. However, scientific validation for Chirata’s anthelmintic efficacy is limited. A few in vitro and animal studies suggest that extracts of Swertia chirata may have moderate activity against certain helminths, most notably in laboratory settings using worms like Pheretima posthuma (earthworm models). Nonetheless, these studies are preliminary, often use non-human subjects, and do not directly address nematodes or clinically relevant human parasites. There are no high-quality clinical trials or robust human data confirming its efficacy for this indication. In summary, while Chirata is traditionally used for parasitic infections, especially intestinal worms, scientific evidence supporting this use is weak and mostly preclinical. Its use for this purpose remains grounded in traditional practice rather than validated modern research.

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