Combretum quadrangulare, a plant native to Southeast Asia, has a well-documented history of use in traditional medicine for treating parasitic infections, particularly intestinal worms (nematodes). This traditional use is supported by several scientific studies. The most significant evidence comes from in vitro and in vivo experiments, particularly from Thailand and Vietnam, showing that extracts from the seeds and roots of Combretum quadrangulare exhibit notable anthelmintic activity. For example, research published in the Journal of Ethnopharmacology (2001) demonstrated that alcoholic extracts of the seeds were effective in reducing worm burden in mice infected with Trichinella spiralis and Heligmosomoides polygyrus. The active compounds are believed to include triterpenes and flavonoids, although the precise mechanisms of action are still being explored.

While the studies provide promising results, most have been conducted on animal models or through in vitro assays. There is limited clinical data on effectiveness or safety in humans, so the evidence, though stronger than purely traditional claims, does not reach the highest level of scientific validation. Nonetheless, the convergence of traditional use and emerging scientific support justifies its moderate rating for this indication.