Phyllanthus fraternus has a history of traditional use in various systems of medicine, particularly in Ayurveda and folk medicine, for the treatment of intestinal parasites such as nematodes and worms. The whole plant or its extracts are typically administered as decoctions or infusions for this purpose. Ethnobotanical surveys and traditional medicine texts from India and other tropical regions document its use as an anthelmintic (anti-parasitic) agent. However, the scientific evidence supporting this use is limited. A few in vitro and in vivo studies on related Phyllanthus species (such as Phyllanthus niruri) have demonstrated some degree of anthelmintic activity, but direct studies specifically on Phyllanthus fraternus are scarce. The available research suggests the presence of phytochemicals such as lignans, flavonoids, and tannins, which may contribute to anti-parasitic effects, but robust clinical or pharmacological studies are lacking. In summary, while the use of Phyllanthus fraternus against intestinal parasites is well-rooted in tradition and supported by anecdotal evidence, scientific validation remains minimal. The current evidence base does not robustly confirm efficacy, so its use for this purpose should be considered traditional, with a modest level of supporting evidence.