Evidence supporting the use of: Saponins (unspecified)
For the health condition: Parasites (nematodes, worms)

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Saponins, a diverse group of naturally occurring glycosides found in many plants, have a long history of use in traditional medicine for the treatment of parasitic infections, particularly those caused by nematodes and other helminths. Ethnobotanical records document the use of saponin-rich plants such as soapwort (Saponaria officinalis), quinoa (Chenopodium quinoa), and various legumes in folk remedies aimed at expelling intestinal worms. The proposed mechanism is based on the surfactant properties of saponins, which can disrupt cell membranes and potentially damage or immobilize parasites within the gastrointestinal tract. Some in vitro and animal studies suggest that saponins can affect the viability and motility of nematodes and other helminths. For example, laboratory studies have shown saponin extracts reducing egg hatch or larval viability in certain worm species. However, clinical trials in humans are very limited, and most claims are based on traditional usage rather than strong scientific validation. The evidence from modern pharmacology is promising but preliminary, not yet reaching the level of robust, standardized interventions. As such, while there is a basis in both traditional use and some experimental data, the overall quality and consistency of evidence supporting saponins as an effective anti-parasitic treatment is modest.

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