Evidence supporting the use of: Alpha-GPC
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Alpha-GCP (Alpha-glycerylphosphorylcholine, often abbreviated as Alpha-GPC) is primarily recognized for its role as a choline source and its effects on cognitive function and neurological health. There is some scientific evidence suggesting that Alpha-GPC can influence the autonomic nervous system, including the parasympathetic branch, but this is not its primary or most well-studied use. Some animal and limited human studies indicate that Alpha-GPC may enhance acetylcholine synthesis, a neurotransmitter crucial for parasympathetic nervous system activity. Increased acetylcholine availability could, in theory, support parasympathetic functions such as rest, digestion, and relaxation. However, most human clinical research on Alpha-GPC focuses on its potential to improve memory, cognitive performance, and recovery in stroke patients, rather than direct support of the parasympathetic nervous system.

A 2003 study (Ziegenfuss et al.) reported that Alpha-GPC supplementation increased growth hormone secretion and fat oxidation, possibly via cholinergic mechanisms, but did not directly measure parasympathetic activity. There is a lack of robust, direct evidence from controlled trials specifically linking Alpha-GPC to improved parasympathetic nervous system function in humans. Thus, while there is a plausible scientific mechanism, the overall quality and quantity of supporting evidence remains limited, meriting a modest rating.

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