Evidence supporting the use of: Bacopasides
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Bacopasides are a class of saponins found in Bacopa monnieri, an herb traditionally used in Ayurvedic medicine for cognitive enhancement and stress reduction. Scientific studies have focused on Bacopa’s neuroprotective, anxiolytic, and adaptogenic properties. There is moderate evidence that Bacopa extracts, containing bacopasides, exert effects on the autonomic nervous system, particularly by enhancing parasympathetic (rest-and-digest) activity. Preclinical studies have shown that Bacopa can increase vagal tone, reduce cortisol levels, and promote relaxation behaviors in animal models. In humans, several small-scale randomized controlled trials have reported that Bacopa supplementation can lower heart rate and reduce self-reported stress, suggesting a shift towards parasympathetic dominance. However, the direct link between isolated bacopasides and specific modulation of the parasympathetic nervous system is less established; most research uses whole-plant extracts rather than purified compounds. While the evidence is promising and consistent with traditional uses for stress and anxiety, larger and more rigorous clinical trials are needed to confirm the specific effects of bacopasides on the parasympathetic nervous system.

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Products containing Bacopasides

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