Evidence supporting the use of: GABA
For the body system: Parasympathetic Nervous System

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Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter in the central nervous system, playing a key role in reducing neuronal excitability and promoting relaxation. Its use as a supplement to support the parasympathetic nervous system (PNS)—which governs "rest and digest" functions—is based on the scientific understanding that GABAergic activity is associated with calming effects and stress reduction. Some studies have shown that oral GABA supplementation can lead to measurable physiological changes such as reduced heart rate and increased alpha brain waves, which are indicative of relaxation and parasympathetic activation. For example, a small number of clinical trials in humans have reported that GABA supplementation may help decrease stress markers and promote relaxation after exposure to stressful tasks.

However, the evidence is limited and somewhat controversial because it is unclear how much orally administered GABA actually crosses the blood-brain barrier to exert direct effects on the brain. Some proponents suggest that GABA may influence the enteric nervous system or exert indirect effects via the gut-brain axis. Despite these uncertainties, GABA supplements are widely marketed for their calming and "parasympathetic-supporting" properties.

In summary, there is some scientific rationale and limited clinical evidence for the use of GABA in supporting the parasympathetic nervous system, but the overall quality and quantity of evidence is low, justifying a modest rating.

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