Evidence supporting the use of: Jaborandi
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 3

Jaborandi, derived from the leaves of the Pilocarpus species, has a long history of traditional use, particularly in South American indigenous medicine. The primary active compound in Jaborandi is pilocarpine, a well-known alkaloid that acts as a parasympathomimetic agent. Pilocarpine directly stimulates muscarinic receptors, leading to increased secretion by exocrine glands (such as saliva and sweat) and promoting physiological responses typical of parasympathetic nervous system activation. Historically, Jaborandi was used to induce sweating and treat conditions like dry mouth (xerostomia) and glaucoma. While pilocarpine itself is scientifically validated and approved for medical uses related to the parasympathetic nervous system, the use of whole Jaborandi leaf or crude preparations is primarily supported by traditional practices rather than modern clinical trials. Most current scientific evidence and approvals focus on purified pilocarpine rather than the herb itself. Therefore, the evidence supporting Jaborandi’s effect on the parasympathetic nervous system is rooted in its traditional use and the pharmacological properties of pilocarpine, but not in robust clinical trial data for Jaborandi as a whole herb.

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