Relationship: Parasympathetic Nervous System and l-glycine

Evidence supporting the use of: L-glycine
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glycine is a non-essential amino acid that functions as an inhibitory neurotransmitter in the central nervous system, including regions involved in parasympathetic activity. There is some scientific evidence that glycine can promote relaxation and support autonomic balance. Glycine binds to specific glycine receptors in the brain and spinal cord, leading to inhibitory effects that may help modulate stress responses and promote a state of calmness. Some studies have suggested that glycine supplementation can improve sleep quality, reduce core body temperature, and decrease subjective feelings of fatigue, which may indirectly support parasympathetic (rest-and-digest) functions.

However, while these effects are promising, direct evidence linking glycine supplementation specifically to enhanced parasympathetic nervous system activity in humans is limited. Most research focuses on its role in sleep and general nervous system inhibition rather than direct modulation of parasympathetic tone. Animal studies and in vitro experiments provide some mechanistic support, but robust clinical trials are lacking.

In summary, there is preliminary scientific evidence suggesting that L-glycine may support relaxation and sleep, which are associated with parasympathetic activity. However, the evidence base for its direct support of the parasympathetic nervous system is modest, meriting a rating of 2 out of 5.

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beta caryophyllene
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chrysanthemum
citrus sinensis (proprietary)
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cowage seed
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dioscorea
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fava bean
GABA (gamma aminobutyric acid)
galantamine
gardenia
gastrodia
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ginseng
Ginsenosides
guayusa
haliotis
herbal blend (proprietary)
Honokiol
hops
huperzine A
Jatamansi
jiaogulan
jujube
jujubosides
kava
kavalactones
kudzu
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L-taurine
L-theanine
lactium casein decapeptide
lavender
lemon balm
lemongrass
lion's mane
lotus seed
lupulinum
magnesium
magnolia
Motherwort
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Nymphaea caerulea
passionflower
phytocannabinoids
Polygala
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rosavins
sceletium
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skullcap
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Valerenic acid
Valerian root
vitamin B
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Other body systems supported by L-glycine

Brain
Digestive System
Gastrointestinal Tract
Immune System
Liver
Mitochondria
Muscles
Nerves
Parasympathetic Nervous System
Skin

Products containing L-glycine

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Evidence supporting the use of: L-glycine
For the body system: Parasympathetic Nervous System

Table of Contents

Synopsis

Other ingredients that support Parasympathetic Nervous System

Other body systems supported by L-glycine

Products containing L-glycine

Health Concerns

Brands

Evidence supporting the use of: L-glycineFor the body system: Parasympathetic Nervous System

Table of Contents

Synopsis

Other ingredients that support Parasympathetic Nervous System

Other body systems supported by L-glycine

Products containing L-glycine

Evidence supporting the use of: L-glycine
For the body system: Parasympathetic Nervous System