Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Lactium, a patented casein decapeptide (αs1-casein hydrolysate), has been studied for its potential calming effects and its ability to support the parasympathetic nervous system, which is responsible for "rest and digest" functions in the body. The scientific rationale centers on Lactium's proposed activity as a "bioactive peptide" that can bind to GABA-A receptors in the brain, similar to the mechanism of some anxiolytic drugs, thereby promoting relaxation and reducing stress-related symptoms. Several small randomized controlled trials and animal studies have shown that Lactium supplementation may reduce biomarkers of stress (such as cortisol), improve sleep quality, and decrease self-reported anxiety. For example, a 2006 human clinical trial published in the journal Stress demonstrated that Lactium intake was associated with lower blood pressure and improved heart rate variability, both indicators of enhanced parasympathetic activity. However, most clinical studies are limited in size and duration, and many are sponsored by the ingredient’s manufacturer. While preliminary evidence is promising and supports a moderate effect, independent large-scale studies are lacking, and the exact mechanism remains to be fully elucidated. Thus, the use of Lactium to support the parasympathetic nervous system is supported by scientific evidence, but the overall quality and quantity of the data are moderate rather than robust.

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