Evidence supporting the use of: Passionflower
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Passionflower (Passiflora incarnata) has a long history of traditional use as a calming herb, but there is also scientific evidence supporting its effects on the nervous system, particularly regarding its ability to promote relaxation and support the parasympathetic branch. The parasympathetic nervous system is responsible for the 'rest and digest' response, and passionflower appears to support this by acting on the GABAergic system, which is involved in reducing neuronal excitability.

Several clinical studies and preclinical trials indicate that passionflower extract can reduce symptoms of anxiety, improve sleep quality, and promote relaxation. For example, a randomized controlled trial (Akhondzadeh et al., 2001) found passionflower extract was as effective as oxazepam (a benzodiazepine) in managing generalized anxiety disorder, with fewer side effects. Animal studies support these findings, showing increased GABA levels in the brain after passionflower administration, which correlates with inhibitory, calming effects.

However, while evidence is promising, it is not yet robust or large-scale enough to warrant a higher rating. Most trials are small and vary in methodology and dosing, and not all have specifically measured direct effects on the parasympathetic nervous system, though the downstream effects of increased GABAergic activity are consistent with enhanced parasympathetic tone. Thus, passionflower’s use for supporting relaxation and parasympathetic balance is both traditional and increasingly scientifically validated, meriting a moderate evidence score.

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