Evidence supporting the use of: Rosavins
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosavins are a group of active compounds found in the plant Rhodiola rosea, commonly known as "golden root" or "arctic root." There is a moderate degree of scientific evidence suggesting that Rhodiola rosea extracts, standardized to contain rosavins, may support aspects of the parasympathetic nervous system (PNS), primarily through their adaptogenic effects on stress modulation. Several randomized controlled trials and animal studies have indicated that Rhodiola rosea can help the body resist physical, chemical, and biological stressors by modulating the hypothalamic-pituitary-adrenal (HPA) axis and reducing cortisol levels. Some research suggests that by reducing stress-induced sympathetic nervous system activity, rosavins may indirectly promote parasympathetic activity, leading to improved relaxation, reduced fatigue, and enhanced recovery following stress.

However, while the evidence supports Rhodiola’s general adaptogenic and anti-fatigue effects, direct measurement of parasympathetic nervous system activity (such as changes in heart rate variability or vagal tone) in response to rosavins is limited. Most clinical studies focus on subjective reports of well-being, mental performance, and fatigue, rather than specific physiological markers of PNS activation. Thus, while there is scientific support for a role in stress adaptation—potentially benefiting the parasympathetic system—the evidence for direct, robust effects on the PNS is moderate and not conclusive.

In summary, rosavins are supported by scientific evidence for stress adaptation and fatigue reduction, with plausible, though not definitively proven, benefits for PNS activity.

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