Evidence supporting the use of: Rosavins (mixed)
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Rosavins are a group of compounds found in the root of Rhodiola rosea, a plant traditionally used in Russian and Scandinavian herbal medicine as an adaptogen. Modern research has investigated its effects on stress responses, fatigue, and mental performance. Several studies propose that Rhodiola extracts, standardized for rosavins and salidroside, can modulate the body's stress response, potentially by influencing the hypothalamic-pituitary-adrenal (HPA) axis and neurotransmitter levels. The parasympathetic nervous system (PNS) governs 'rest and digest' functions, and adaptogens like Rhodiola have been suggested to increase parasympathetic activity by balancing autonomic nervous system responses under stress. Some human trials report that Rhodiola supplementation can reduce perceived stress and fatigue, which may indirectly support PNS activity. However, direct studies measuring rosavins' effect on PNS biomarkers are limited. Most available evidence is derived from broader adaptogenic effects rather than direct action on parasympathetic pathways, and often involves whole Rhodiola extracts rather than isolated rosavins. Thus, while there is moderate scientific support for the use of rosavin-containing Rhodiola extracts in stress adaptation—potentially benefiting the PNS—the evidence specifically linking rosavins to direct PNS support is limited, warranting an evidence rating of 3 out of 5.

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