Evidence supporting the use of: Sceletium
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Sceletium tortuosum, commonly known as kanna or kougoed, has a long history of traditional use in South Africa, where indigenous peoples, particularly the San and Khoikhoi, have used it for centuries primarily to relieve stress, elevate mood, and support relaxation. The plant contains alkaloids such as mesembrine, which are thought to influence serotonin pathways in the brain. While these effects are primarily associated with mood and stress, some proponents suggest that by reducing stress and promoting relaxation, Sceletium may indirectly support the parasympathetic nervous system (PNS) — the branch of the autonomic nervous system responsible for 'rest-and-digest' functions.

However, direct scientific evidence linking Sceletium to specific modulation or support of the parasympathetic nervous system is limited. Most modern research has focused on its anxiolytic and antidepressant-like effects in animal models and small human trials, rather than specific autonomic nervous system endpoints. Therefore, while there is a basis in tradition for using Sceletium to promote relaxation and wellbeing (which could be associated with parasympathetic dominance), the evidence for direct PNS support is weak and largely inferential, not experimentally established.

In summary, the use of Sceletium to support the parasympathetic nervous system is primarily justified by traditional usage patterns related to stress relief and mood enhancement, with little direct scientific validation for its effects on the PNS specifically.

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