Evidence supporting the use of: Uncaria rhynchophylla
For the body system: Parasympathetic Nervous System

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Synopsis

Source of validity: Traditional
Rating (out of 5): 2

Uncaria rhynchophylla, commonly known as Gou Teng, has a long history of use in Traditional Chinese Medicine (TCM). It is primarily used to calm the liver, extinguish wind, and alleviate symptoms such as headaches, dizziness, and convulsions, which are believed in TCM to be associated with liver yang rising and internal wind. Some traditional practitioners interpret these calming and sedative effects as supporting the parasympathetic nervous system, although this is a modern reinterpretation rather than a classical TCM concept.

Scientific studies on Uncaria rhynchophylla have shown that certain alkaloids found in the plant, such as rhynchophylline and isorhynchophylline, possess neuroprotective and anticonvulsant effects in animal models. There is limited evidence that these compounds can modulate neurotransmitter systems and reduce neuronal excitability, which may be loosely associated with increased parasympathetic tone or reduced sympathetic activity. However, direct clinical evidence supporting its use specifically for strengthening or supporting the parasympathetic nervous system in humans is lacking.

In summary, the use of Uncaria rhynchophylla to support the parasympathetic nervous system is primarily justified by traditional use and some preclinical evidence for calming neurological effects, but not by robust clinical trials or direct evidence of parasympathetic modulation.

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