Evidence supporting the use of: Withanolides
For the body system: Parasympathetic Nervous System

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Table of Contents

Synopsis

Source of validity: Scientific
Rating (out of 5): 3

Withanolides are a group of naturally occurring steroidal lactones, most notably found in Withania somnifera (Ashwagandha), a prominent herb in Ayurvedic medicine. Scientific studies have investigated the adaptogenic and neuroprotective effects of withanolides, focusing on their impact on stress responses, anxiety, and overall nervous system function. The parasympathetic nervous system (PNS) is responsible for promoting relaxation and recovery in the body, counterbalancing the sympathetic "fight or flight" responses.

Preclinical studies (in vitro and animal models) indicate that withanolides can modulate neurotransmitter levels, reduce oxidative stress, and enhance neurogenesis. Human clinical trials on Ashwagandha extracts standardized to withanolide content have shown reductions in perceived stress, anxiety, and cortisol levels, outcomes that are consistent with enhanced parasympathetic activity. For example, a 2019 randomized controlled trial reported significant reductions in stress and improvements in well-being in participants taking Ashwagandha extract compared to placebo. These findings suggest that withanolides may support the PNS indirectly by promoting a "rest and digest" physiological state and improving the body's resilience to stress.

While more research is needed to define the specific mechanisms and direct effects on the PNS, the available evidence supports the traditional use of withanolides for nervous system support and provides a moderate scientific basis for their role in supporting parasympathetic function.

More about Withanolides
More about Parasympathetic Nervous System

Products containing Withanolides

We currently have no products on Vitabase that contain this ingredient.