Evidence supporting the use of: 1,3,7-Trimethylpurine-2,6-dione
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 3

1,3,7-Trimethylpurine-2,6-dione is the chemical name for caffeine. Scientific evidence supports a potential role for caffeine in Parkinson's disease (PD), primarily in terms of risk reduction rather than direct treatment. Observational studies over several decades have consistently shown that regular caffeine consumption is associated with a lower risk of developing Parkinson's disease. The proposed mechanism involves caffeine's antagonistic action at adenosine A2A receptors in the brain, which influences the dopaminergic system implicated in PD pathology.

Some clinical trials have investigated caffeine's symptomatic effects in diagnosed Parkinson's patients. For example, a 2012 randomized controlled trial (Postuma et al., Neurology, 2012) found that 200 mg of caffeine twice daily for 6 weeks modestly improved objective motor symptoms in PD patients. However, these improvements were not robust or sustained, and later studies did not confirm significant long-term benefits for established PD symptoms. The current consensus is that while there is strong epidemiological evidence for a protective association, there is only modest and inconclusive evidence supporting caffeine as a symptomatic treatment for people already diagnosed with PD.

In summary, caffeine is scientifically studied in relation to Parkinson's disease, mainly for prevention rather than treatment. Its use is not based on tradition but on epidemiological and mechanistic research, warranting a moderate evidence rating of 3 for supportive or preventive roles, but not as a primary PD therapy.

More about 1,3,7-Trimethylpurine-2,6-dione
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1,3,7-Trimethylpurine-2,6-dione
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Products containing 1,3,7-Trimethylpurine-2,6-dione

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