Evidence supporting the use of: 7,8-Dihydroxyflavone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

7,8-Dihydroxyflavone (7,8-DHF) is a small-molecule compound that acts as a selective agonist of the TrkB receptor, mimicking brain-derived neurotrophic factor (BDNF) activity. BDNF-TrkB signaling is known to play a crucial role in neuronal survival, plasticity, and repair, processes that are disrupted in neurodegenerative diseases such as Parkinson’s Disease (PD). Preclinical studies have investigated the neuroprotective effects of 7,8-DHF in various models of PD. For example, administration of 7,8-DHF in rodent models has been shown to protect dopaminergic neurons from toxin-induced degeneration, improve motor function, and reduce oxidative stress and inflammation in the substantia nigra. These findings suggest a potential disease-modifying effect in PD, at least in animal models.

However, there is currently no robust clinical evidence supporting the use of 7,8-DHF in humans with Parkinson’s Disease. The evidence base consists almost entirely of laboratory and animal studies (e.g., Chen et al., 2015, Neurobiology of Disease; Jang et al., 2010, PNAS), with a lack of published human trials. Therefore, while the scientific rationale and preclinical results are promising, the overall strength of evidence is rated as moderate to low (2/5) due to the absence of human data. More clinical research is needed to determine safety, efficacy, and appropriate dosing in humans before 7,8-DHF can be recommended for PD.

More about 7,8-Dihydroxyflavone
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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing 7,8-Dihydroxyflavone

We currently have no products on Vitabase that contain this ingredient.