Evidence supporting the use of: Acetyl L-carnitine
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl L-carnitine (ALCAR) has been explored as a potential adjunct treatment for Parkinson’s Disease (PD), but the scientific evidence is limited and not conclusive. The rationale for its use stems from its roles in mitochondrial function, energy metabolism, and neuroprotection. Preclinical studies have shown that ALCAR may protect dopaminergic neurons from oxidative stress and mitochondrial dysfunction, both implicated in the pathogenesis of PD. Additionally, some animal studies suggest that ALCAR may improve motor performance and reduce neuronal loss in models of PD. In humans, a few small-scale clinical trials have examined ALCAR in PD patients. These studies generally report modest benefits, such as improvements in cognitive function, mood, or fatigue, but not consistently in primary motor symptoms of PD. A 2007 randomized controlled trial found minor improvements in mood and attention in PD patients receiving ALCAR, but no significant changes in motor scores. Systematic reviews conclude that while ALCAR appears safe and well-tolerated, there is insufficient high-quality evidence to recommend its use as a standard treatment for PD. Most professional guidelines do not include ALCAR for PD management. In summary, scientific evidence partially supports the use of acetyl L-carnitine in PD, mainly for possible neuroprotective and cognitive effects, but current data are limited and not robust enough to strongly validate its clinical efficacy for this indication.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone