Evidence supporting the use of: Acetyl L-carnitine
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Acetyl L-carnitine (ALCAR) has been explored as a potential adjunct treatment for Parkinson’s Disease (PD), but the scientific evidence is limited and not conclusive. The rationale for its use stems from its roles in mitochondrial function, energy metabolism, and neuroprotection. Preclinical studies have shown that ALCAR may protect dopaminergic neurons from oxidative stress and mitochondrial dysfunction, both implicated in the pathogenesis of PD. Additionally, some animal studies suggest that ALCAR may improve motor performance and reduce neuronal loss in models of PD. In humans, a few small-scale clinical trials have examined ALCAR in PD patients. These studies generally report modest benefits, such as improvements in cognitive function, mood, or fatigue, but not consistently in primary motor symptoms of PD. A 2007 randomized controlled trial found minor improvements in mood and attention in PD patients receiving ALCAR, but no significant changes in motor scores. Systematic reviews conclude that while ALCAR appears safe and well-tolerated, there is insufficient high-quality evidence to recommend its use as a standard treatment for PD. Most professional guidelines do not include ALCAR for PD management. In summary, scientific evidence partially supports the use of acetyl L-carnitine in PD, mainly for possible neuroprotective and cognitive effects, but current data are limited and not robust enough to strongly validate its clinical efficacy for this indication.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)