Evidence supporting the use of: Agmatine
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Agmatine is a naturally occurring compound derived from the amino acid arginine. Its use in relation to Parkinson's Disease (PD) is supported by early-stage scientific research, mostly preclinical studies. In animal models of PD, agmatine has demonstrated neuroprotective effects, potentially through modulation of NMDA receptors, inhibition of nitric oxide synthase, and reduction of oxidative stress and neuroinflammation. Some studies have shown that agmatine can attenuate dopaminergic neuron loss and improve motor deficits in rodent models of PD.

Despite these promising findings, there is a lack of robust clinical evidence in humans. No large-scale, well-controlled clinical trials have been published to confirm efficacy or safety of agmatine supplementation in people with Parkinson’s Disease. The available evidence is therefore limited to cell culture experiments and animal studies, which do not always translate successfully to human outcomes. Agmatine is not a traditional remedy for PD, nor is it currently an established part of mainstream medical treatment for the condition.

In summary, while there is a scientific rationale and some preliminary evidence from laboratory studies supporting agmatine’s potential neuroprotective role in Parkinson’s Disease, clinical validation in humans is lacking. Its use remains experimental and should not be considered a proven or standard therapy for PD at this time.

More about Agmatine
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Agmatine

We currently have no products on Vitabase that contain this ingredient.