Evidence supporting the use of: Bacoside
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Bacoside, a major active constituent of Bacopa monnieri (commonly known as Brahmi), has been studied in the context of neurodegenerative diseases, including Parkinson’s Disease (PD). The use of bacosides for PD is primarily justified by preclinical scientific research rather than traditional use. In animal models, bacosides have demonstrated neuroprotective effects, including antioxidative action, inhibition of neuronal apoptosis, and reduction of neuroinflammation. Studies in rodent models of PD—induced by neurotoxins such as 6-hydroxydopamine or MPTP—have shown that bacoside administration can attenuate motor deficits, preserve dopaminergic neurons in the substantia nigra, and reduce markers of oxidative stress and inflammation in the brain (e.g., Uabundit et al., 2014).

However, clinical trials in humans with Parkinson’s Disease are lacking, and the evidence is not sufficient to recommend bacoside as a treatment for PD. The current evidence comes from in vitro studies and animal models, which suggest a potential mechanism for neuroprotection but do not establish efficacy or safety in humans with PD. Thus, while bacosides are scientifically investigated for their neuroprotective properties, the overall evidence for their use in Parkinson’s Disease remains preliminary (rated 2/5).

In summary, bacoside’s use in PD is supported by early-stage scientific research, not by tradition or robust clinical evidence. More rigorous human studies are needed to confirm any therapeutic benefit in Parkinson’s Disease.

More about bacoside
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing bacoside

We currently have no products on Vitabase that contain this ingredient.