Evidence supporting the use of: Baicalin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Baicalin is a flavonoid compound primarily derived from the roots of Scutellaria baicalensis (Chinese skullcap), a traditional herbal medicine. Its use in Parkinson's Disease (PD) is not rooted in traditional medicine but is instead supported by emerging preclinical scientific research. Several in vitro and animal studies suggest that baicalin may have neuroprotective properties relevant to PD. These effects are mainly attributed to its antioxidant, anti-inflammatory, and anti-apoptotic actions. For instance, studies in rodent models of PD (such as those induced by MPTP or 6-OHDA toxins) have demonstrated that baicalin administration can attenuate dopaminergic neuron loss in the substantia nigra, reduce oxidative stress markers, and decrease levels of pro-inflammatory cytokines. Mechanistically, baicalin is thought to modulate pathways such as Nrf2/ARE for antioxidant defense and inhibit microglial activation to reduce neuroinflammation. However, no robust human clinical trials have confirmed these benefits in people with PD. The existing evidence is limited to laboratory and animal models, and the translation to clinical efficacy remains unproven. Therefore, while there is some scientific rationale and preclinical support for baicalin as a potential adjunct in PD, the evidence is currently weak (rated 2/5) and insufficient for clinical recommendations at this time.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing baicalin

We currently have no products on Vitabase that contain this ingredient.