Evidence supporting the use of: Biopterin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Biopterin and Parkinson's Disease: Scientific Evidence Overview

Biopterin refers to a group of compounds related to tetrahydrobiopterin (BH4), a critical cofactor in the synthesis of several neurotransmitters, including dopamine. Parkinson's Disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to dopamine deficiency. Given BH4's role in dopamine biosynthesis (as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in dopamine production), there is a plausible biochemical rationale for exploring its use in PD.

Several studies have shown that BH4 levels may be reduced in the brains of individuals with PD. Experimental and early clinical research has investigated whether supplementation with BH4 can improve dopamine synthesis or alleviate symptoms. Some small-scale trials and case reports suggest that BH4 supplementation may modestly improve motor symptoms in select PD patients, particularly when combined with other dopaminergic treatments. However, results have been inconsistent, and overall clinical benefit remains unproven.

Major neurology guidelines do not currently recommend biopterin or BH4 supplementation as standard therapy for PD. The evidence base is limited by small sample sizes, lack of robust randomized controlled trials, and variable clinical outcomes. Thus, while there is a scientific rationale and some preliminary research, the overall quality and consistency of the evidence supporting biopterin use in PD is low.

More about Biopterin
More about Parkinson's Disease

Other health conditions supported by Biopterin

Autism
Depression
Parkinson's Disease

Products containing Biopterin

We currently have no products on Vitabase that contain this ingredient.