Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Biopterin and Parkinson's Disease: Scientific Evidence Overview

Biopterin refers to a group of compounds related to tetrahydrobiopterin (BH₄), a critical cofactor in the synthesis of several neurotransmitters, including dopamine. Parkinson's Disease (PD) is characterized by the degeneration of dopaminergic neurons in the substantia nigra, leading to dopamine deficiency. Given BH₄'s role in dopamine biosynthesis (as a cofactor for tyrosine hydroxylase, the rate-limiting enzyme in dopamine production), there is a plausible biochemical rationale for exploring its use in PD.

Several studies have shown that BH₄ levels may be reduced in the brains of individuals with PD. Experimental and early clinical research has investigated whether supplementation with BH₄ can improve dopamine synthesis or alleviate symptoms. Some small-scale trials and case reports suggest that BH₄ supplementation may modestly improve motor symptoms in select PD patients, particularly when combined with other dopaminergic treatments. However, results have been inconsistent, and overall clinical benefit remains unproven.

Major neurology guidelines do not currently recommend biopterin or BH₄ supplementation as standard therapy for PD. The evidence base is limited by small sample sizes, lack of robust randomized controlled trials, and variable clinical outcomes. Thus, while there is a scientific rationale and some preliminary research, the overall quality and consistency of the evidence supporting biopterin use in PD is low.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Other health conditions supported by Biopterin

Autism
Depression
Parkinson's Disease

Products containing Biopterin

We currently have no products on Vitabase that contain this ingredient.