Evidence supporting the use of: Carnosic acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carnosic acid is a polyphenolic diterpene compound primarily found in rosemary (Rosmarinus officinalis) and sage (Salvia officinalis). Its potential neuroprotective properties have attracted scientific interest in the context of neurodegenerative diseases, including Parkinson’s Disease (PD). Preclinical studies suggest that carnosic acid acts as an antioxidant, can modulate neuroinflammation, and may activate the Nrf2/ARE pathway, which upregulates endogenous antioxidant enzymes in neuronal cells. In various cell culture and animal models of PD, carnosic acid has demonstrated protective effects against dopaminergic neuronal loss induced by toxins such as MPTP and 6-OHDA, which are commonly used to model PD pathology. These studies report reduced oxidative stress, inhibition of apoptosis, and partial preservation of motor function in treated animals.

However, to date, there are no published clinical trials in humans directly evaluating the efficacy of carnosic acid for treating or slowing the progression of Parkinson’s Disease. The available evidence is therefore limited to in vitro and animal research, which, while promising, does not provide sufficient grounds for clinical recommendations. Traditional medicine does not specifically cite carnosic acid or rosemary extracts for PD treatment. In summary, while there is some scientific rationale and encouraging preclinical data, the current level of evidence for carnosic acid’s use in PD is preliminary and rated a 2 out of 5.

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