Evidence supporting the use of: Carnosic acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Carnosic acid is a polyphenolic diterpene compound primarily found in rosemary (Rosmarinus officinalis) and sage (Salvia officinalis). Its potential neuroprotective properties have attracted scientific interest in the context of neurodegenerative diseases, including Parkinson’s Disease (PD). Preclinical studies suggest that carnosic acid acts as an antioxidant, can modulate neuroinflammation, and may activate the Nrf2/ARE pathway, which upregulates endogenous antioxidant enzymes in neuronal cells. In various cell culture and animal models of PD, carnosic acid has demonstrated protective effects against dopaminergic neuronal loss induced by toxins such as MPTP and 6-OHDA, which are commonly used to model PD pathology. These studies report reduced oxidative stress, inhibition of apoptosis, and partial preservation of motor function in treated animals.

However, to date, there are no published clinical trials in humans directly evaluating the efficacy of carnosic acid for treating or slowing the progression of Parkinson’s Disease. The available evidence is therefore limited to in vitro and animal research, which, while promising, does not provide sufficient grounds for clinical recommendations. Traditional medicine does not specifically cite carnosic acid or rosemary extracts for PD treatment. In summary, while there is some scientific rationale and encouraging preclinical data, the current level of evidence for carnosic acid’s use in PD is preliminary and rated a 2 out of 5.

More about carnosic acid
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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing carnosic acid

We currently have no products on Vitabase that contain this ingredient.