Evidence supporting the use of: Catalpol
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Catalpol is an iridoid glycoside primarily found in the roots of Rehmannia glutinosa, a traditional Chinese medicinal herb. Recent preclinical studies have investigated its potential neuroprotective effects in models of Parkinson's Disease (PD). In animal and cellular models, catalpol has shown the ability to reduce dopaminergic neuronal loss, decrease oxidative stress, and inhibit neuroinflammation, which are key pathological features of PD. Mechanistic studies suggest catalpol may exert its effects through antioxidative pathways, inhibition of apoptosis, and modulation of neurotrophic factors such as BDNF (Brain-Derived Neurotrophic Factor). However, it is important to note that all current evidence comes from laboratory and animal research. There are no published clinical trials in humans evaluating the efficacy or safety of catalpol for PD. While its traditional use focuses more broadly on kidney and brain health, its specific application in Parkinson's Disease is a recent development driven by scientific exploration rather than longstanding traditional practice. Therefore, while there is preliminary scientific support for catalpol’s neuroprotective potential in PD, this evidence is limited in quality and quantity, and its clinical relevance remains unproven.

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