Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Coenzyme Q10 (CoQ10) has been investigated as a potential adjunctive treatment for Parkinson’s Disease (PD) primarily due to its role as an antioxidant and its involvement in mitochondrial energy production. Scientific interest began when research showed mitochondrial dysfunction and oxidative stress in the substantia nigra of PD patients. Early pilot studies and a notable 2002 randomized controlled trial suggested that high doses of CoQ10 might slow functional decline in PD patients, generating considerable interest in its neuroprotective potential. However, subsequent larger and more rigorous studies, such as the multicenter Phase III QE3 trial published in 2014, failed to show any significant benefit of CoQ10 supplementation (at doses up to 2400 mg/day) in slowing PD progression compared to placebo. Meta-analyses and systematic reviews consistently conclude that while CoQ10 is generally safe and well-tolerated, there is insufficient evidence to recommend it as a disease-modifying treatment for Parkinson’s Disease. Thus, while there is scientific rationale for its use and it has been studied in clinical trials, the overall quality and consistency of evidence supporting its efficacy is low (rated 2 out of 5). Its use in PD is not based on traditional or folk medicine practices, but rather on modern biomedical hypotheses and clinical research.

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Other ingredients used for Parkinson's Disease

Other health conditions supported by coenzyme Q10 (CoQ10)

Products containing coenzyme Q10 (CoQ10)

Pure Encapsulations Athletic Nutrients
Douglas Laboratories Citrus-Q10 ™
Douglas Laboratories Co-Enzyme Q10 Softgel
Douglas Laboratories Coenzyme Q-10 with Lipoic Acid
Douglas Laboratories Coenzyme Q-10 with Lipoic Acid
Integrative Therapeutics CoQ10
Integrative Therapeutics COQ10 100 mg Tropical
Pure Encapsulations CoQ10 120 mg
Pure Encapsulations CoQ10 120 mg
Pure Encapsulations CoQ10 120 mg
Integrative Therapeutics COQ10 200 mg Chocolate 30 chew tabs
Pure Encapsulations CoQ10 250 mg
Pure Encapsulations CoQ10 30 mg
Pure Encapsulations CoQ10 500 mg
Pure Encapsulations CoQ10 60 mg
Pure Encapsulations CoQ10 60 mg
Pure Encapsulations CoQ10 60 mg
Pure Encapsulations CoQ10 l-Carnitine Fumarate
Thorne CoQ10 Q-Best 100
Metagenics CoQ10 ST®-100 mg
Metagenics CoQ10 ST-100 mg
Metagenics CoQ10 ST-200 mg
Integrative Therapeutics Detoxication Factors
Integrative Therapeutics Detoxication Factors
Pure Encapsulations Energize Plus™ Pure Pack
Pure Encapsulations Hair/Skin/Nails Ultra
Thorne Heart Health Complex Q-10 Plus
Integrative Therapeutics K-PAX MitoNutrients
Vitabase Life's Essentials Plus
Designs For Health Mito-NR™
Pure Encapsulations Mitochondria-ATP
Designs For Health Mitochondrial NRG™
Pure Encapsulations NeuroMood Pure Pack
Metagenics NutraGems® CoQ10 300
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Pure Encapsulations O.N.E.™ Multivitamin
Thorne Omega-3 w/ CoQ10
Thorne Ovarian Care
Integrative Therapeutics ProThrivers Wellness Flav Complex
Pure Encapsulations PureGenomics® UltraMultivitamin
Designs For Health Q-Evail® 100
Designs For Health Q-Evail® 200
Pure Encapsulations Q-Gel® (Hydrosoluble™ CoQ10) 100 mg
Thorne Red Yeast Rice + CoQ10 Choleast
Pure Encapsulations Renual
Pure Encapsulations RevitalAge™ Nerve
Pure Encapsulations RevitalAge™ Ultra
Designs For Health RYR Synergy™
Pure Encapsulations SR-CoQ10 with PQQ
Vitabase Super Fat Burner
Pure Encapsulations Ubiquinol-QH 100 mg
Pure Encapsulations Ubiquinol-QH 200 mg
Pure Encapsulations Ubiquinol VESIsorb®
Integrative Therapeutics UBQH 100 mg
Douglas Laboratories Ultra Preventive 50+ -EZ Swallow
Douglas Laboratories Ultra Preventive One Daily
Pure Encapsulations Ultra Pure Pack
Pure Encapsulations UltraDetox 10-Day Pure Pack
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Pure Encapsulations UltraNutrient®
Metagenics Wellness Essentials Brain Health Daily Packs