Evidence supporting the use of: Creatine
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Creatine has been investigated as a potential neuroprotective agent in Parkinson’s Disease (PD) based on its known role in cellular energy metabolism and mitochondrial function. Preclinical studies in animal models suggested that creatine supplementation could enhance neuronal survival and slow neurodegeneration, likely by supporting ATP production and reducing oxidative stress. This led to the launch of several clinical trials in humans to assess creatine’s efficacy for PD.

The most significant human study was the multicenter, randomized, double-blind, placebo-controlled Phase III trial (the NET-PD LS-1 study), which enrolled over 1,700 participants with early Parkinson’s Disease. This trial tested whether creatine supplementation could slow the progression of disability in PD patients receiving standard treatment. The study was halted early in 2013 after interim analysis showed no benefit of creatine over placebo in slowing disease progression. Other smaller trials and meta-analyses have similarly failed to demonstrate a meaningful clinical benefit for creatine in PD patients.

In summary, while initial scientific rationale and preclinical data supported the exploration of creatine for Parkinson’s Disease, large-scale clinical evidence does not support its use for this indication. Therefore, creatine is not recommended as a treatment for Parkinson’s Disease based on current scientific evidence.

More about creatine
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing creatine

We currently have no products on Vitabase that contain this ingredient.