Evidence supporting the use of: Creatine
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Creatine has been investigated as a potential neuroprotective agent in Parkinson’s Disease (PD) based on its known role in cellular energy metabolism and mitochondrial function. Preclinical studies in animal models suggested that creatine supplementation could enhance neuronal survival and slow neurodegeneration, likely by supporting ATP production and reducing oxidative stress. This led to the launch of several clinical trials in humans to assess creatine’s efficacy for PD.

The most significant human study was the multicenter, randomized, double-blind, placebo-controlled Phase III trial (the NET-PD LS-1 study), which enrolled over 1,700 participants with early Parkinson’s Disease. This trial tested whether creatine supplementation could slow the progression of disability in PD patients receiving standard treatment. The study was halted early in 2013 after interim analysis showed no benefit of creatine over placebo in slowing disease progression. Other smaller trials and meta-analyses have similarly failed to demonstrate a meaningful clinical benefit for creatine in PD patients.

In summary, while initial scientific rationale and preclinical data supported the exploration of creatine for Parkinson’s Disease, large-scale clinical evidence does not support its use for this indication. Therefore, creatine is not recommended as a treatment for Parkinson’s Disease based on current scientific evidence.

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