Evidence supporting the use of: Curcumin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Curcumin, the active compound in turmeric, has been studied for its potential neuroprotective effects, including in Parkinson’s Disease (PD). While curcumin is not a traditional remedy specifically for PD, its historical use in Ayurvedic medicine for general inflammatory and neurological conditions has prompted scientific investigation into its effects on neurodegenerative diseases. Preclinical studies (mainly in vitro and animal models) indicate that curcumin may exert beneficial effects in PD through multiple mechanisms: reducing oxidative stress, inhibiting neuroinflammation, and preventing the aggregation of alpha-synuclein, a key pathological process in PD. Curcumin also appears to modulate signaling pathways involved in neuronal survival and may protect dopaminergic neurons from degeneration.

However, the evidence from human clinical trials is extremely limited. There is a lack of robust, large-scale randomized controlled trials assessing curcumin’s efficacy and safety specifically in PD patients. Most studies are preliminary, with small sample sizes or are limited to laboratory models. Issues with curcumin’s bioavailability also present a significant challenge to its therapeutic use. Therefore, while there is a scientific rationale and encouraging preclinical evidence to support curcumin’s potential in PD, the current level of clinical evidence is weak (rated 2/5). More research, especially well-designed human studies, is necessary before curcumin can be recommended as a proven treatment for Parkinson’s Disease.

More about curcumin
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)