Evidence supporting the use of: Cyanidin-3-glucoside
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 1

Cyanidin-3-glucoside (C3G) is a type of anthocyanin widely found in berries and colored fruits and vegetables. Its potential use in supporting or treating Parkinson’s Disease (PD) is based on preclinical scientific investigations rather than traditional medicine or widespread clinical practice. The current evidence comes primarily from in vitro studies and animal models, which suggest that C3G has antioxidant, anti-inflammatory, and neuroprotective properties. These properties are relevant because oxidative stress and neuroinflammation are significant contributors to the pathogenesis of PD. Several rodent studies have shown that C3G can reduce dopaminergic neuronal loss and improve motor function in toxin-induced models of PD, likely through mechanisms involving the inhibition of oxidative damage, reduction in pro-inflammatory cytokines, and modulation of apoptotic pathways. However, there are no robust human clinical trials to date evaluating the efficacy or safety of C3G specifically for Parkinson’s Disease. Thus, while there is preliminary scientific rationale and experimental evidence, it is insufficient to recommend C3G for clinical use in PD. The evidence is rated low (1/5) as it is limited to basic science and preclinical studies, with no confirmation from human trials.

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