Evidence supporting the use of: Decarboxylase
For the health condition: Parkinson's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 5
Decarboxylase itself is not directly administered as a treatment for Parkinson’s Disease; rather, decarboxylase inhibitors (such as carbidopa or benserazide) are essential adjuncts to levodopa therapy. Parkinson’s Disease is characterized by a deficiency of dopamine in the brain. Levodopa, a dopamine precursor, can cross the blood-brain barrier, where it is converted to dopamine by the enzyme aromatic L-amino acid decarboxylase (AADC or DOPA decarboxylase). However, when levodopa is administered alone, a significant amount is converted to dopamine in the periphery (outside the brain), leading to decreased efficacy and increased side effects.
To address this, decarboxylase inhibitors are co-administered with levodopa. These inhibitors block the action of AADC in the periphery, allowing more levodopa to reach the brain, where it can be converted to dopamine. This combination is supported by robust clinical evidence and forms the standard of care in Parkinson’s Disease management. Numerous randomized controlled trials and decades of clinical practice have demonstrated that the addition of a decarboxylase inhibitor to levodopa therapy significantly improves motor symptoms and reduces side effects like nausea and cardiovascular complications. Therefore, the use of decarboxylase inhibitors in Parkinson’s Disease is strongly justified by scientific evidence.
Other ingredients used for Parkinson's Disease
1,3,7-Trimethylpurine-2,6-dione7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)