Relationship: Parkinson's Disease and DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

DHA (docosahexaenoic acid) is an omega-3 polyunsaturated fatty acid found abundantly in the brain and is vital for normal brain function. The rationale for using DHA in Parkinson’s Disease (PD) is primarily based on its neuroprotective and anti-inflammatory properties. Preclinical studies, including animal models of PD, have shown that DHA supplementation can reduce dopaminergic neuron loss, oxidative stress, and neuroinflammation—key features in the progression of PD. Furthermore, some observational studies in humans have found that higher dietary omega-3 intake is associated with a reduced risk of developing Parkinson’s Disease. However, direct clinical evidence in humans is limited.

A handful of small clinical trials have explored omega-3 fatty acids, including DHA, as adjunctive therapy in PD patients. These studies suggest potential benefits such as modest improvement in depressive symptoms and quality of life, but effects on core motor symptoms of PD are inconsistent or minimal. Systematic reviews and meta-analyses generally conclude that while there is a biological rationale and supportive evidence from animal studies, robust clinical trials demonstrating clear efficacy in humans are lacking. Consequently, DHA is sometimes recommended as an adjunct for its general brain health benefits but not as a primary therapy for PD.

In summary, while there is a scientific rationale and some preliminary evidence for DHA’s neuroprotective effects in PD, definitive clinical validation is lacking, and evidence strength is modest (rated 2/5).

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Other ingredients used for Parkinson's Disease

acetyl l-carnitine
akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
l-carnosine
l-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid

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Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Health Concerns

Brands

Evidence supporting the use of: DHA (docosahexaeonic acid)For the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by DHA (docosahexaeonic acid)

Products containing DHA (docosahexaeonic acid)

Evidence supporting the use of: DHA (docosahexaeonic acid)
For the health condition: Parkinson's Disease