Evidence supporting the use of: Eicosapentaenoic acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic Acid (EPA) is an omega-3 polyunsaturated fatty acid found primarily in fish oil, and its use in Parkinson’s Disease (PD) is supported by limited scientific evidence. The rationale for EPA supplementation in PD is based on its potential neuroprotective, anti-inflammatory, and membrane-stabilizing effects. Some small-scale clinical studies and preclinical research suggest that omega-3 fatty acids, including EPA, can reduce neuroinflammation and oxidative stress, both implicated in PD pathogenesis. For example, a randomized controlled trial (da Silva et al., 2008) found that omega-3 supplementation, combined with antioxidant vitamins, led to improvements in depression symptoms in PD patients. However, its direct effect on the motor symptoms or progression of PD remains unclear, and larger, high-quality trials are lacking.

EPA is not a standard or primary therapy for PD, and medical guidelines do not currently recommend its use for disease modification or symptomatic management. The evidence base is limited to small studies with mixed outcomes, and most research has focused on the general neuroprotective effects of omega-3s rather than EPA specifically. As such, while there is scientific interest and some preliminary data, the strength of evidence is weak and does not support routine use of EPA as a treatment for Parkinson’s Disease at this time.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing eicosapentaenoic acid

We currently have no products on Vitabase that contain this ingredient.