Relationship: Parkinson's Disease and EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Parkinson's Disease

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Source of validity: Scientific
Rating (out of 5): 2

Eicosapentaenoic acid (EPA), an omega-3 polyunsaturated fatty acid, has some scientific rationale for its use in supporting Parkinson's Disease (PD), though the overall evidence is limited and preliminary. Parkinson’s Disease is characterized by the degeneration of dopaminergic neurons in the brain, with inflammation and oxidative stress playing significant roles in its pathology. EPA is known for its anti-inflammatory and neuroprotective properties, which have been explored in various neurodegenerative diseases, including PD.

A small number of clinical studies and animal models have evaluated EPA supplementation in PD. Some open-label trials and pilot randomized controlled trials have suggested that EPA, and omega-3 fatty acids in general, may help alleviate depressive symptoms in PD patients, which are common non-motor symptoms. Furthermore, animal studies indicate that EPA might reduce neuroinflammation and oxidative damage, thereby potentially providing neuroprotection. However, evidence for direct motor symptom improvement or disease modification in PD patients is lacking.

Meta-analyses and systematic reviews generally conclude that while omega-3 fatty acids, including EPA, show promise for mood symptoms in PD, there is insufficient high-quality evidence to recommend their routine use for core Parkinson’s symptoms. Thus, the use of EPA in PD is justified by a scientific rationale and limited early evidence, but robust clinical validation is currently lacking.

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Other ingredients used for Parkinson's Disease

acetyl l-carnitine
akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
l-carnosine
l-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid

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Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Health Concerns

Brands

Evidence supporting the use of: EPA (eicosapentaenoic acid)For the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by EPA (eicosapentaenoic acid)

Products containing EPA (eicosapentaenoic acid)

Evidence supporting the use of: EPA (eicosapentaenoic acid)
For the health condition: Parkinson's Disease