Evidence supporting the use of: Epigallo catechin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin gallate (EGCG), the major catechin in green tea, has been investigated for its potential neuroprotective effects relevant to Parkinson's Disease (PD). Preclinical studies in cell cultures and animal models suggest that EGCG may protect dopaminergic neurons by reducing oxidative stress, inhibiting apoptosis, and modulating pathways involved in neuroinflammation and mitochondrial dysfunction—key processes implicated in PD pathogenesis. Some studies have demonstrated that EGCG can attenuate the loss of dopaminergic neurons and improve motor function in toxin-induced models of PD. EGCG is also noted to inhibit aggregation of alpha-synuclein, the protein that forms Lewy bodies in PD brains.

However, clinical evidence in humans is limited. There are currently no large-scale, well-controlled clinical trials demonstrating significant benefit of EGCG supplementation for PD patients. Most of the available data come from in vitro or animal studies, and while these are promising, they do not guarantee efficacy or safety in humans. Some epidemiological studies suggest that higher green tea consumption may be associated with a reduced risk of PD, but confounding factors limit interpretation.

In summary, while there is some scientific rationale and preclinical evidence supporting the potential use of EGCG in PD, clinical evidence is lacking and does not yet justify its use as a treatment. More research, particularly in the form of clinical trials, is needed to establish efficacy and safety in PD patients.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Epigallo catechin

We currently have no products on Vitabase that contain this ingredient.