Evidence supporting the use of: Epigallocatechin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin, most commonly referenced as epigallocatechin gallate (EGCG), is a polyphenol found abundantly in green tea. Its use in supporting or treating Parkinson’s Disease (PD) is primarily justified by scientific interest rather than longstanding traditional use. Preclinical studies have demonstrated that EGCG possesses antioxidant, anti-inflammatory, and neuroprotective properties, all relevant to the pathogenesis of PD, which involves oxidative stress and dopaminergic neuronal loss. Several in vitro and animal studies have indicated that EGCG can reduce neurotoxicity, decrease alpha-synuclein aggregation (a hallmark of PD), and protect dopaminergic neurons from degeneration. EGCG has also been shown to modulate signaling pathways implicated in neuronal survival and apoptosis. However, despite promising preclinical data, evidence from human studies is limited and inconclusive. Clinical trials evaluating EGCG in Parkinson’s patients are scarce, with most data derived from laboratory models rather than human subjects. Some small studies have explored green tea consumption and PD risk, suggesting a potential protective effect, but these are observational and not specific to EGCG supplementation. Overall, while the scientific rationale exists and preliminary evidence is encouraging, robust clinical trials are lacking. Thus, the current evidence supporting EGCG’s use in Parkinson’s Disease is best rated as weak to moderate (2/5) and should not be considered a validated treatment at this time.

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