Evidence supporting the use of: Epigallocatechin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Epigallocatechin, most commonly referenced as epigallocatechin gallate (EGCG), is a polyphenol found abundantly in green tea. Its use in supporting or treating Parkinson’s Disease (PD) is primarily justified by scientific interest rather than longstanding traditional use. Preclinical studies have demonstrated that EGCG possesses antioxidant, anti-inflammatory, and neuroprotective properties, all relevant to the pathogenesis of PD, which involves oxidative stress and dopaminergic neuronal loss. Several in vitro and animal studies have indicated that EGCG can reduce neurotoxicity, decrease alpha-synuclein aggregation (a hallmark of PD), and protect dopaminergic neurons from degeneration. EGCG has also been shown to modulate signaling pathways implicated in neuronal survival and apoptosis. However, despite promising preclinical data, evidence from human studies is limited and inconclusive. Clinical trials evaluating EGCG in Parkinson’s patients are scarce, with most data derived from laboratory models rather than human subjects. Some small studies have explored green tea consumption and PD risk, suggesting a potential protective effect, but these are observational and not specific to EGCG supplementation. Overall, while the scientific rationale exists and preliminary evidence is encouraging, robust clinical trials are lacking. Thus, the current evidence supporting EGCG’s use in Parkinson’s Disease is best rated as weak to moderate (2/5) and should not be considered a validated treatment at this time.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Epigallocatechin

We currently have no products on Vitabase that contain this ingredient.