Evidence supporting the use of: Ergothioneine
For the health condition: Parkinson's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Ergothioneine is a naturally occurring amino acid antioxidant found in foods such as mushrooms, beans, and oat bran. Its potential role in neurodegenerative diseases, including Parkinson's Disease (PD), has garnered interest due to its antioxidant and cytoprotective properties. Several preclinical studies indicate that ergothioneine can cross the blood-brain barrier via the OCTN1 transporter, and it accumulates in tissues prone to oxidative stress, such as the brain. Oxidative stress is a key mechanism implicated in the degeneration of dopaminergic neurons in PD.
However, direct clinical evidence supporting ergothioneine's efficacy in treating or preventing PD is lacking. A few observational studies have reported lower plasma ergothioneine levels in patients with cognitive impairment and neurodegenerative diseases, suggesting a potential association. Some animal studies suggest neuroprotective effects, including the attenuation of oxidative damage and neuroinflammation, but these have not yet translated into randomized clinical trials in humans with Parkinson's Disease.
In summary, the use of ergothioneine for Parkinson's Disease is supported by plausible biological mechanisms and some preclinical data, but robust clinical validation is absent. Thus, the evidence level is low (2/5), and ergothioneine cannot be recommended as a proven therapeutic option for Parkinson's Disease at this time.
Other ingredients used for Parkinson's Disease
1,3,7-Trimethylpurine-2,6-dione7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)