Evidence supporting the use of: Ferulic acid derivative
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ferulic acid derivatives have garnered scientific interest for their potential neuroprotective effects in Parkinson’s Disease (PD), primarily based on preclinical studies. Ferulic acid is a plant-derived phenolic compound with antioxidant, anti-inflammatory, and anti-apoptotic properties. In animal and cell models of PD, ferulic acid and its derivatives have been shown to attenuate dopaminergic neuronal loss, reduce oxidative stress, inhibit neuroinflammation, and modulate mitochondrial dysfunction—mechanisms that are relevant to PD pathogenesis. For instance, studies published in peer-reviewed journals such as Neurochemistry International and Neurotoxicity Research have demonstrated that ferulic acid treatment protected against neurotoxicity induced by MPTP and 6-OHDA, two toxins commonly used to model PD in rodents.

Despite these promising preclinical findings, clinical evidence in humans is lacking. No substantial randomized controlled trials or large cohort studies have been conducted to establish efficacy or safety of ferulic acid derivatives in PD patients. Thus, while there is a scientific rationale and early experimental support for their use, the current evidence is limited to laboratory research and does not yet justify clinical application. Further studies, particularly in humans, are required to validate these benefits and determine appropriate dosing and safety profiles.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Ferulic acid derivative

We currently have no products on Vitabase that contain this ingredient.