Evidence supporting the use of: Fish oil
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been investigated for its potential role in supporting neurodegenerative conditions, including Parkinson’s Disease (PD). The scientific rationale is based on omega-3’s anti-inflammatory and neuroprotective properties, as neuroinflammation and oxidative stress are implicated in PD pathogenesis. Animal studies have shown that omega-3 supplementation may reduce dopaminergic neuron loss in PD models.

In humans, evidence is limited and mixed. Some small clinical trials suggest that omega-3 supplementation may improve certain non-motor symptoms of PD, such as depression, but robust data on motor symptom improvement or disease progression are lacking. For example, a 2008 pilot trial (da Silva et al., 2008) suggested that omega-3 supplementation combined with antidepressants had a positive effect on depressive symptoms in PD patients. However, larger, high-quality randomized controlled trials specifically addressing fish oil’s effects on core PD symptoms are lacking.

Overall, while there is a plausible biological mechanism and some preliminary positive findings—especially regarding mood symptoms—the scientific evidence supporting fish oil’s role in directly treating or slowing Parkinson’s Disease remains weak. Its use is not supported by tradition in the context of PD specifically. Further research is needed before fish oil can be routinely recommended as a supportive therapy for Parkinson’s Disease.

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Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
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