Evidence supporting the use of: Fish oil
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Fish oil, rich in omega-3 polyunsaturated fatty acids (PUFAs) such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), has been investigated for its potential role in supporting neurodegenerative conditions, including Parkinson’s Disease (PD). The scientific rationale is based on omega-3’s anti-inflammatory and neuroprotective properties, as neuroinflammation and oxidative stress are implicated in PD pathogenesis. Animal studies have shown that omega-3 supplementation may reduce dopaminergic neuron loss in PD models.

In humans, evidence is limited and mixed. Some small clinical trials suggest that omega-3 supplementation may improve certain non-motor symptoms of PD, such as depression, but robust data on motor symptom improvement or disease progression are lacking. For example, a 2008 pilot trial (da Silva et al., 2008) suggested that omega-3 supplementation combined with antidepressants had a positive effect on depressive symptoms in PD patients. However, larger, high-quality randomized controlled trials specifically addressing fish oil’s effects on core PD symptoms are lacking.

Overall, while there is a plausible biological mechanism and some preliminary positive findings—especially regarding mood symptoms—the scientific evidence supporting fish oil’s role in directly treating or slowing Parkinson’s Disease remains weak. Its use is not supported by tradition in the context of PD specifically. Further research is needed before fish oil can be routinely recommended as a supportive therapy for Parkinson’s Disease.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaenoic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
Melatonin
N-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
apigenin
Agmatine
astragalin
biopterin
baicalein
brahmi
broad bean
bacoside
baicalin
catalpol
creatine
C-phycocyanin
cannabidiol
carnosic acid
decarboxylase
ergothioneine
eicosapentaenoic acid
fo-ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
gastrodin
Haematococcus pluvialis
Honokiol
hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
mangiferin
Myricetin
magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
pyrroloquinoline quinone
Puerarin
paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
Trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone