Evidence supporting the use of: Gastrodin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Gastrodin is a bioactive compound derived from Gastrodia elata, a traditional Chinese medicinal herb. Its use in Parkinson’s Disease (PD) is supported by preclinical evidence rather than robust clinical trials. Animal studies and in vitro experiments have shown that gastrodin exhibits neuroprotective effects, which could be relevant for PD, a neurodegenerative disorder characterized by the loss of dopaminergic neurons. Proposed mechanisms include antioxidant effects, inhibition of neuroinflammation, reduction of oxidative stress, and suppression of apoptotic pathways in neuronal cells. For example, several studies in rodent PD models have demonstrated that gastrodin can ameliorate motor deficits and reduce dopaminergic neuron loss, likely by modulating pathways such as the Nrf2/ARE antioxidant response and reducing the activation of microglia.

Despite these promising findings, evidence in humans is lacking. There are no large-scale, double-blind, placebo-controlled clinical trials evaluating gastrodin’s efficacy or safety in patients with Parkinson’s Disease. Its use in PD is thus currently experimental, and while it is referenced in some traditional medicine practices for neurological conditions, its direct application to PD is based on modern pharmacological studies rather than long-standing traditional use.

In summary, while gastrodin has demonstrated neuroprotective properties in laboratory settings, clinical validation for its use in Parkinson’s Disease is absent, and recommendations for its use are based primarily on preclinical data.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing gastrodin

We currently have no products on Vitabase that contain this ingredient.