Evidence supporting the use of: Ginsenosides
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ginsenosides are the primary active compounds in ginseng (Panax ginseng) and have been investigated for their potential neuroprotective effects, including in Parkinson’s Disease (PD). Preclinical studies, mainly in cell cultures and animal models, suggest that certain ginsenosides (such as Rg1, Rb1, and Rd) may exert neuroprotective effects by reducing oxidative stress, inhibiting apoptosis (cell death), modulating neuroinflammation, and improving mitochondrial function—all processes implicated in PD pathophysiology. Some studies have demonstrated that ginsenosides can protect dopaminergic neurons from toxins used to model PD in animals, and may improve motor symptoms in these models.

However, human clinical evidence is minimal. There are no large-scale, high-quality randomized controlled trials (RCTs) assessing the efficacy of ginsenosides in treating or slowing the progression of Parkinson’s Disease in humans. Most evidence comes from laboratory and animal studies, which do not always translate to clinical efficacy in humans. Because of this, while there is a scientific basis for ongoing research, the current level of evidence supporting the use of ginsenosides for Parkinson’s Disease is weak (rated 2 out of 5). Ginsenosides are not considered a standard or established treatment for PD, but ongoing preclinical research supports further exploration.

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