Evidence supporting the use of: Glycosphingolipids
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycosphingolipids have recently emerged as a potential therapeutic target in Parkinson’s Disease (PD) based on mechanistic and preclinical scientific evidence. Glycosphingolipids are a class of lipids involved in cell membrane structure and cell signaling. Mutations in the GBA gene, which encodes the enzyme glucocerebrosidase responsible for glycosphingolipid metabolism, are one of the most common genetic risk factors for PD. These mutations cause impaired lysosomal function and accumulation of glycosphingolipids, which may contribute to alpha-synuclein aggregation—a hallmark of PD pathology.

Preclinical studies in cell and animal models have shown that modulating glycosphingolipid metabolism or enhancing glucocerebrosidase activity can reduce alpha-synuclein accumulation and improve neuronal survival. Several clinical trials are underway to test small molecule modulators of glucocerebrosidase (such as ambroxol) and substrate reduction therapies targeting glycosphingolipid synthesis in PD patients, particularly those with GBA mutations.

Despite these promising mechanistic and early clinical findings, conclusive evidence of benefit from glycosphingolipid-targeted therapies in PD patients is not yet available. There is no tradition of using glycosphingolipids for PD treatment. Current use is justified by emerging scientific understanding, but clinical efficacy and safety remain to be fully established.

More about Glycosphingolipids
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Other ingredients used for Parkinson's Disease

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7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
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Xanthine
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Products containing Glycosphingolipids

We currently have no products on Vitabase that contain this ingredient.