Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Glycosphingolipids have recently emerged as a potential therapeutic target in Parkinson’s Disease (PD) based on mechanistic and preclinical scientific evidence. Glycosphingolipids are a class of lipids involved in cell membrane structure and cell signaling. Mutations in the GBA gene, which encodes the enzyme glucocerebrosidase responsible for glycosphingolipid metabolism, are one of the most common genetic risk factors for PD. These mutations cause impaired lysosomal function and accumulation of glycosphingolipids, which may contribute to alpha-synuclein aggregation—a hallmark of PD pathology.

Preclinical studies in cell and animal models have shown that modulating glycosphingolipid metabolism or enhancing glucocerebrosidase activity can reduce alpha-synuclein accumulation and improve neuronal survival. Several clinical trials are underway to test small molecule modulators of glucocerebrosidase (such as ambroxol) and substrate reduction therapies targeting glycosphingolipid synthesis in PD patients, particularly those with GBA mutations.

Despite these promising mechanistic and early clinical findings, conclusive evidence of benefit from glycosphingolipid-targeted therapies in PD patients is not yet available. There is no tradition of using glycosphingolipids for PD treatment. Current use is justified by emerging scientific understanding, but clinical efficacy and safety remain to be fully established.

More about Glycosphingolipids
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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Other health conditions supported by Glycosphingolipids

Autoimmune Disorders
Inflammation
Inflammatory Bowel Disorders
Memory and Brain Function
Parkinson's Disease

Products containing Glycosphingolipids

We currently have no products on Vitabase that contain this ingredient.