Evidence supporting the use of: Hericium mushroom
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Hericium erinaceus, commonly known as Lion's Mane mushroom, has gained attention for its potential neuroprotective properties, particularly in relation to neurodegenerative diseases like Parkinson’s Disease (PD). Its use is justified by emerging scientific research rather than a long tradition of use specifically for PD. Preclinical studies, mainly in cell culture and animal models, suggest that compounds in Hericium, such as hericenones and erinacines, can promote nerve growth factor (NGF) synthesis, enhance neuronal survival, and reduce neuroinflammation and oxidative stress—processes implicated in PD pathology.

Some animal studies have reported that extracts of Hericium can protect dopaminergic neurons (the primary neurons lost in PD) and improve motor function in toxin-induced models of Parkinson’s. However, robust clinical evidence in humans is lacking. Only a few small pilot studies or case reports are available, and these do not provide definitive conclusions regarding efficacy or safety for PD patients. No major clinical trials have yet confirmed its benefits in PD.

In summary, while there is promising preclinical evidence supporting the neuroprotective potential of Hericium erinaceus, especially in mechanisms relevant to Parkinson’s Disease, human clinical data are insufficient. Thus, scientific support exists but is preliminary, and the overall evidence is rated as low to moderate (2 out of 5) at this time.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing hericium mushroom

We currently have no products on Vitabase that contain this ingredient.