Evidence supporting the use of: Honokiol
For the health condition: Parkinson's Disease
Synopsis
Source of validity: Scientific
Rating (out of 5): 2
Honokiol, a bioactive compound extracted from the bark of Magnolia species, has been investigated in preclinical studies for its neuroprotective effects relevant to Parkinson’s Disease (PD). The scientific interest arises from honokiol's antioxidant, anti-inflammatory, and anti-apoptotic properties, which are mechanisms implicated in the pathophysiology of PD. Several in vitro and animal studies have shown that honokiol can reduce dopaminergic neuronal death, inhibit microglial activation, and decrease oxidative stress in models simulating PD, such as those using the neurotoxins MPTP or rotenone. For example, a 2018 study in "Frontiers in Pharmacology" demonstrated that honokiol pretreatment alleviated behavioral impairments and dopaminergic neuron loss in MPTP-induced mouse models of PD. Additionally, honokiol appears to modulate mitochondrial function and may influence pathways like Nrf2, which is involved in cellular antioxidant defense. However, the evidence supporting honokiol’s use in human PD patients is currently lacking; there are no published clinical trials evaluating its efficacy or safety in this population. The existing animal and cellular data are promising, suggesting neuroprotective potential, but translation to human therapy remains unproven. Therefore, while there is a scientific rationale based on preclinical research, the overall evidence is limited and further clinical studies are needed to determine its therapeutic value for Parkinson's Disease.
Other ingredients used for Parkinson's Disease
1,3,7-Trimethylpurine-2,6-dione7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)