Evidence supporting the use of: Honokiol
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Honokiol, a bioactive compound extracted from the bark of Magnolia species, has been investigated in preclinical studies for its neuroprotective effects relevant to Parkinson’s Disease (PD). The scientific interest arises from honokiol's antioxidant, anti-inflammatory, and anti-apoptotic properties, which are mechanisms implicated in the pathophysiology of PD. Several in vitro and animal studies have shown that honokiol can reduce dopaminergic neuronal death, inhibit microglial activation, and decrease oxidative stress in models simulating PD, such as those using the neurotoxins MPTP or rotenone. For example, a 2018 study in "Frontiers in Pharmacology" demonstrated that honokiol pretreatment alleviated behavioral impairments and dopaminergic neuron loss in MPTP-induced mouse models of PD. Additionally, honokiol appears to modulate mitochondrial function and may influence pathways like Nrf2, which is involved in cellular antioxidant defense. However, the evidence supporting honokiol’s use in human PD patients is currently lacking; there are no published clinical trials evaluating its efficacy or safety in this population. The existing animal and cellular data are promising, suggesting neuroprotective potential, but translation to human therapy remains unproven. Therefore, while there is a scientific rationale based on preclinical research, the overall evidence is limited and further clinical studies are needed to determine its therapeutic value for Parkinson's Disease.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Honokiol

We currently have no products on Vitabase that contain this ingredient.