Evidence supporting the use of: Isoliquiritigenin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoliquiritigenin is a flavonoid compound found in licorice root (Glycyrrhiza uralensis and related species) that has been investigated in preclinical studies for its neuroprotective properties, including potential benefits in models of Parkinson’s Disease (PD). The interest in isoliquiritigenin for PD primarily stems from its antioxidant, anti-inflammatory, and anti-apoptotic effects demonstrated in cell culture and animal models. Several studies have shown that isoliquiritigenin can reduce oxidative stress and inhibit neuroinflammation—two central mechanisms implicated in the degeneration of dopaminergic neurons in Parkinson’s Disease. For example, animal studies have reported that isoliquiritigenin administration can ameliorate motor deficits and reduce the loss of dopaminergic neurons induced by neurotoxins such as MPTP or rotenone, which are commonly used to model PD pathology in rodents. These effects are thought to be mediated through modulation of signaling pathways including Nrf2/ARE, inhibition of microglial activation, and reduction of pro-inflammatory cytokines.

However, there is currently no direct clinical evidence in humans to support the use of isoliquiritigenin as a treatment for Parkinson’s Disease. Its use is justified by preclinical scientific research rather than traditional medicine, as it is not a historically recognized remedy for PD. Thus, while the mechanistic and animal data are promising, the evidence level remains low (rated 2/5) pending human trials.

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Other ingredients used for Parkinson's Disease

1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Acetyl L-carnitine
Agmatine
Akkermansia muciniphila
algal oil
AMP-activated protein kinase (AMPK)
apigenin
ashwagandha
astragalin
bacoside
baicalein
baicalin
beta caryophyllene
biopterin
black garlic
brahmi
broad bean
butyrate triglyceride
C-phycocyanin
cannabidiol
carnosic acid
catalpol
catechins
citicoline
coenzyme Q10 (CoQ10)
creatine
curcumin
decarboxylase
DHA (docosahexaenoic acid)
eicosapentaenoic acid
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
ergothioneine
fava bean
ferulic acid
fisetin
fish oil
fo-ti
gastrodin
ginkgo biloba
Ginsenosides
Glucoraphanin
Glycosphingolipids
gotu kola
green tea
Gypenoside
Haematococcus pluvialis
hericium mushroom
Honokiol
icariin
inosine
isoliquiritigenin
Jatamansi
Kaempferol
L-carnosine
L-glutathione
lingzhi
lion's mane
luteolin
magnolol
mangiferin
medium chain triglycerides (MCT)
Melatonin
Myricetin
N-acetyl-cysteine (NAC)
NADH
nicotinamide riboside
Nobiletin
Oleuropein
omega-3 fatty acids
paeoniflorin
Palmitoylethanolamide (PEA)
phosphatidylserine
Phosphocreatine
phytocannabinoids
Puerain
Puerarin
pyrroloquinoline quinone
quercetin
resveratrol
Salidroside
Salvianolic acid
SAMe (S-adenosyl-L-methionine disulfate p-toluensulfate)
Shilajit
specialized pro-resolving mediators (SPMs)
spirulina
Sulforaphane
sulforaphane glucosinolate
Tanshinone
Trehalose
Triacetyluridine
Tumerone
ubiquinol
Uncaria
Urolithin A
velvet bean
vitamin D
vitamin D3
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone
β-nicotinamide mononucleotide (NMN)

Products containing isoliquiritigenin

We currently have no products on Vitabase that contain this ingredient.