Evidence supporting the use of: Isoliquiritigenin
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Isoliquiritigenin is a flavonoid compound found in licorice root (Glycyrrhiza uralensis and related species) that has been investigated in preclinical studies for its neuroprotective properties, including potential benefits in models of Parkinson’s Disease (PD). The interest in isoliquiritigenin for PD primarily stems from its antioxidant, anti-inflammatory, and anti-apoptotic effects demonstrated in cell culture and animal models. Several studies have shown that isoliquiritigenin can reduce oxidative stress and inhibit neuroinflammation—two central mechanisms implicated in the degeneration of dopaminergic neurons in Parkinson’s Disease. For example, animal studies have reported that isoliquiritigenin administration can ameliorate motor deficits and reduce the loss of dopaminergic neurons induced by neurotoxins such as MPTP or rotenone, which are commonly used to model PD pathology in rodents. These effects are thought to be mediated through modulation of signaling pathways including Nrf2/ARE, inhibition of microglial activation, and reduction of pro-inflammatory cytokines.

However, there is currently no direct clinical evidence in humans to support the use of isoliquiritigenin as a treatment for Parkinson’s Disease. Its use is justified by preclinical scientific research rather than traditional medicine, as it is not a historically recognized remedy for PD. Thus, while the mechanistic and animal data are promising, the evidence level remains low (rated 2/5) pending human trials.

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Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing isoliquiritigenin

We currently have no products on Vitabase that contain this ingredient.