Jatamansi (Nardostachys jatamansi) has a long history of use in traditional Ayurvedic and Unani medicine, where it is valued for its supposed neuroprotective and calming effects. In these traditional systems, Jatamansi is used for a variety of neurological and psychiatric disorders, and is sometimes recommended as an adjunct in the management of symptoms resembling those of Parkinson’s Disease (PD), such as tremors and cognitive decline. The rationale is based on its reputed ability to balance the nervous system and promote mental clarity.

Scientifically, there is limited but emerging evidence from preclinical studies. A few animal studies have suggested that Jatamansi extracts may exert neuroprotective effects, possibly through antioxidant, anti-inflammatory, and MAO-B inhibitory activities. For example, some rodent studies have shown reduced oxidative stress and improvement in motor function in toxin-induced models of PD after administration of Jatamansi. However, these findings are preliminary and not yet confirmed in human clinical trials. There are no robust clinical studies directly supporting its efficacy for Parkinson’s Disease in humans.

In summary, the use of Jatamansi for Parkinson’s Disease is primarily based on traditional practices, with limited scientific evidence (mainly preclinical) suggesting potential neuroprotective effects. High-quality human studies are lacking, so its use remains largely traditional and should be considered with caution.