Evidence supporting the use of: Ketone
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Ketones, specifically in the form of exogenous ketone supplements or ketogenic diets, have attracted scientific interest as a potential adjunct therapy for Parkinson's Disease (PD). The rationale is based on the idea that ketones can serve as an alternative energy substrate for neurons, potentially compensating for impaired glucose metabolism seen in PD. Some preclinical studies in animal models suggest that ketosis may provide neuroprotective effects, possibly by reducing oxidative stress, enhancing mitochondrial function, or modulating neurotransmitter systems. Small pilot clinical studies and case reports in humans indicate that ketogenic diets may offer mild improvements in motor and non-motor symptoms for some individuals with PD, but these studies are limited by small sample sizes, short durations, and lack of blinding. There is insufficient large-scale or long-term clinical data to confirm that ketone supplementation or ketogenic diets have a robust or consistent effect on disease progression or symptom management in Parkinson's Disease. While the mechanistic rationale is promising and early results are encouraging, current scientific evidence rates as preliminary (level 2/5): there is biological plausibility and some initial human data, but not enough to recommend routine use. Further well-designed clinical trials are needed to determine efficacy, safety, and optimal protocols.

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