Evidence supporting the use of: Ketone (unspecified)
For the health condition: Parkinson's Disease

Links: Go back one page, Tool main page, Ingredients list, Health conditions list, Body systems list

Synopsis

Source of validity: Scientific
Rating (out of 5): 2

There is emerging scientific interest in the use of ketones, specifically ketone bodies such as beta-hydroxybutyrate (BHB), as a supportive therapy for Parkinson's Disease (PD). The rationale is based on the observation that PD is characterized by impaired mitochondrial function and reduced energy metabolism in neurons. Ketone bodies, produced during fasting or a ketogenic diet, can serve as alternative energy substrates for the brain when glucose metabolism is compromised. Preclinical studies in animal models have shown that ketogenic diets or administration of exogenous ketones can improve mitochondrial function, enhance neuronal survival, and reduce oxidative stress—all factors implicated in PD pathophysiology. However, clinical evidence in humans remains limited. A handful of small pilot studies and case reports have suggested that ketogenic diets might improve some motor and non-motor symptoms in PD patients, but these studies are preliminary and often lack rigorous controls. There is insufficient large-scale, randomized controlled trial data to conclusively demonstrate efficacy or safety of ketones or ketogenic diets in PD. Thus, while the scientific rationale is plausible and early animal data are promising, human evidence is currently weak and does not yet justify routine clinical use. More research is needed to determine the effectiveness, safety, and long-term impacts of ketone supplementation or ketogenic diets in Parkinson’s Disease patients.

More about ketone (unspecified)
More about Parkinson's Disease

Products containing ketone (unspecified)

We currently have no products on Vitabase that contain this ingredient.