Relationship: Parkinson's Disease and l-glutathione

Evidence supporting the use of: L-glutathione
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-glutathione has been investigated as a potential supportive therapy in Parkinson’s Disease (PD) due to its role as a key antioxidant in the brain. Parkinson’s Disease is associated with oxidative stress and depletion of glutathione in the substantia nigra, a brain region critical for movement. Several small clinical trials and pilot studies have explored whether supplementing with glutathione can help alleviate symptoms or slow disease progression.

Some early open-label and pilot studies suggested that intravenous glutathione might temporarily improve symptoms in PD patients. For example, a 1996 study by Sechi et al. reported mild symptomatic improvement with intravenous glutathione. However, these studies were small and lacked rigorous controls. More recent, larger randomized controlled trials (RCTs) have shown mixed results, with some failing to demonstrate significant clinical benefits over placebo. Oral glutathione is less studied and may be less bioavailable due to breakdown in the digestive tract.

Overall, while there is a plausible biological rationale and some limited preliminary evidence for glutathione’s use in PD, the current scientific evidence is insufficient to recommend it as a standard therapy. Most guidelines do not endorse glutathione supplementation for Parkinson’s Disease outside of clinical trials. More high-quality, large-scale RCTs are needed to clarify its efficacy and safety.

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Other ingredients used for Parkinson's Disease

acetyl l-carnitine
akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
l-carnosine
l-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid

Other health conditions supported by l-glutathione

Acquired Immune Deficiency Syndrome
Autoimmune Disorders
Cancer Treatment (reducing side effects)
Chemotherapy (reducing side effects)
Cirrhosis of the Liver
Diabetes
Fatty Liver Disease
Free Radical Damage
Hepatitis
Inflammation
Liver Detoxification
Nerve Damage
Parkinson's Disease
Peripheral Neuropathy
Radiation Sickness
Sickle Cell Anemia
Skin Care (general)
Ulcers

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Evidence supporting the use of: L-glutathione
For the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by l-glutathione

Products containing l-glutathione

Health Concerns

Brands

Evidence supporting the use of: L-glutathioneFor the health condition: Parkinson's Disease

Table of Contents

Synopsis

Other ingredients used for Parkinson's Disease

Other health conditions supported by l-glutathione

Products containing l-glutathione

Evidence supporting the use of: L-glutathione
For the health condition: Parkinson's Disease