Evidence supporting the use of: L-Gluthathione
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

L-Glutathione has been investigated for its potential role in supporting or treating Parkinson's Disease (PD) based on its antioxidant properties. Parkinson's Disease is characterized by oxidative stress and the degeneration of dopaminergic neurons in the substantia nigra. Glutathione, an endogenous antioxidant, is found at lower levels in the brains of individuals with PD, particularly in affected regions, suggesting a possible link between glutathione depletion and disease progression.

Several small-scale clinical studies and pilot trials have examined intravenous (IV) glutathione as an adjunctive therapy in PD, with some reporting modest improvements in symptoms such as rigidity and tremor. However, these studies are generally limited by small sample sizes, short durations, and lack of rigorous controls or blinding. The mechanism proposed is that supplementing glutathione may help combat oxidative stress, potentially slowing neurodegeneration.

Despite these promising hypotheses and preliminary findings, larger randomized controlled trials have not yet provided strong or consistent evidence to support the routine use of L-glutathione in PD. Moreover, the oral bioavailability of glutathione is poor, and it is unclear whether oral supplementation can effectively increase brain glutathione levels.

In summary, while there is a scientific rationale and limited early research suggesting possible benefit, the current level of evidence supporting L-glutathione for Parkinson’s Disease is weak (rated 2/5), and it is not considered a standard or well-supported therapy for this condition as of 2024.

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