Evidence supporting the use of: Lipoic Acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lipoic acid (also called alpha-lipoic acid, ALA) has been investigated for its potential neuroprotective effects in Parkinson’s Disease (PD), largely due to its antioxidant properties. Experimental studies in cell and animal models of PD have shown that lipoic acid can reduce oxidative stress, improve mitochondrial function, and decrease neuronal damage caused by toxins that induce Parkinson-like symptoms. These mechanisms are relevant because oxidative stress and mitochondrial dysfunction are key contributors to the progression of PD.

However, the evidence in humans is very limited. To date, there have been very few clinical trials evaluating lipoic acid in people with Parkinson's Disease, and those available are small and preliminary. Some studies suggest potential improvement in symptoms or biomarkers of oxidative stress, but results are inconsistent and not robust enough to draw firm conclusions. Systematic reviews and expert guidelines do not currently recommend lipoic acid as a standard or adjunctive treatment for PD.

In summary, while there is preclinical scientific rationale and some early human data suggesting possible benefit, high-quality clinical evidence is lacking. Thus, its use is based on limited scientific evidence (rated 2 out of 5), and further research is needed to establish efficacy and safety for Parkinson’s Disease.

More about Lipoic Acid
More about Parkinson's Disease

Other ingredients used for Parkinson's Disease

Acetyl L-carnitine
Akkermansia muciniphila
algal oil
ashwagandha
beta caryophyllene
black garlic
butyrate triglyceride
catechins
citicoline
coenzyme Q10 (CoQ10)
curcumin
DHA (docosahexaeonic acid)
EPA (eicosapentaenoic acid)
epigallocatechin gallate (EGCG)
fava bean
fisetin
fish oil
ginkgo biloba
gotu kola
green tea
L-carnosine
L-glutathione
lion's mane
luteolin
medium chain triglycerides (MCT)
melatonin
n-acetyl-cysteine (NAC)
nicotinamide riboside
omega-3 fatty acids
phosphatidylserine
phytocannabinoids
quercetin
resveratrol
SAMe (s-adenosyl-l-methionine disulfate p-toluensulfate)
specialized pro-resolving mediators (SPMs)
spirulina
sulforaphane glucosinolate
ubiquinol
Urolithin A
velvet bean
vitamin D
vitamin D3
β-nicotinamide mononucleotide (NMN)
lingzhi
ferulic acid
AMP-activated protein kinase (AMPK)
1,3,7-Trimethylpurine-2,6-dione
7,8-Dihydroxyflavone
Apigenin
Agmatine
Astragalin
Biopterin
Baicalein
Brahmi
Broad Bean
bacoside
Baicalin
Catalpol
Creatine
C-Phycocyanin
Cannabidiol
Carnosic acid
Decarboxylase
Ergothioneine
Eicosapentaenoic Acid
Fo-Ti
Ginsenosides
Gypenoside
Glycosphingolipids
Glucoraphanin
Gastrodin
Haematococcus pluvialis
Honokiol
Hericium mushroom
inosine
isoliquiritigenin
icariin
Jatamansi
Kaempferol
Mangiferin
Myricetin
Magnolol
NADH
Nobiletin
Oleuropein
Phosphocreatine
Puerain
Pyrroloquinoline Quinone
Puerarin
Paeoniflorin
Palmitoylethanolamide (PEA)
Salidroside
Salvianolic acid
Shilajit
Sulforaphane
Tumerone
Tanshinone
trehalose
Triacetyluridine
Uncaria
Vitexin
Withanolides
Wogonin
Xanthine
Xanthohumol
Xanthone

Products containing Lipoic Acid

We currently have no products on Vitabase that contain this ingredient.