Evidence supporting the use of: Lipoic Acid
For the health condition: Parkinson's Disease

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Synopsis

Source of validity: Scientific
Rating (out of 5): 2

Lipoic acid (also called alpha-lipoic acid, ALA) has been investigated for its potential neuroprotective effects in Parkinson’s Disease (PD), largely due to its antioxidant properties. Experimental studies in cell and animal models of PD have shown that lipoic acid can reduce oxidative stress, improve mitochondrial function, and decrease neuronal damage caused by toxins that induce Parkinson-like symptoms. These mechanisms are relevant because oxidative stress and mitochondrial dysfunction are key contributors to the progression of PD.

However, the evidence in humans is very limited. To date, there have been very few clinical trials evaluating lipoic acid in people with Parkinson's Disease, and those available are small and preliminary. Some studies suggest potential improvement in symptoms or biomarkers of oxidative stress, but results are inconsistent and not robust enough to draw firm conclusions. Systematic reviews and expert guidelines do not currently recommend lipoic acid as a standard or adjunctive treatment for PD.

In summary, while there is preclinical scientific rationale and some early human data suggesting possible benefit, high-quality clinical evidence is lacking. Thus, its use is based on limited scientific evidence (rated 2 out of 5), and further research is needed to establish efficacy and safety for Parkinson’s Disease.

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